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Françoise BRINGEL

CNRS research director (DR2)


Université de Strasbourg / CNRS UMR 7156
Laboratoire de Génétique moléculaire, Génomique, Microbiologie
28 rue Goethe, 67083 Strasbourg CEDEX

Tel : + 33 (0)3 68 85 18 15
Fax : + 33 (0)3 68 85 20 28

email : francoise.bringel@unistra.fr

Research interests

  • Comparative genomics of one-carbon compound degradation (https://www.genoscope.cns.fr/agc/microscope/about/collabprojects.php?P_id=26)
  • Comparative genomics of bacterial chlorinated methane metabolism
  • dRNA-seq transcriptomics in Methylobacterium
  • Functional profiling of microbial communities in polluted environments
  • Nucleotide and arginine metabolisms
  • Taxonomy, strain collection curator of Lactobacillus plantarum and related species
  • Gene lateral transfer and genome evolution


75 peer-reviewed publications (see list below or full list of publications)
Researchgate profile at http://www.researchgate.net/profile/Francoise_Bringel/


  • 2014, Tenured CNRS Director (DR2), Université de Strasbourg, France
  • 2014- 1996, Tenured CNRS researcher (CR1), Université de Strasbourg, France
  • 1992-1995, Research CNRS assistant (CR2), Université de Strasbourg, France
  • 1990–1991, Post-doctoral fellow at Emory University, School of Medicine, Atlanta, Georgia, USA (Pr. J. SCOTT)
  • 1986-1990, PhD thesis contract with the French Government of Education and Research


  • 2006, HDR diploma (Habilitation), Microbial diversity and genomic plasticity, University Louis Pasteur, France
  • 1990, Ph. D. in Molecular and Cellular Biology, University Louis Pasteur, France
  • 1986, M. Sc. In Molecular and Cellular Biology, University Louis Pasteur, France

Scientific and academic responsabilities

  • Supervision

    • Of 6 Ph.D. thesis:
      Bruno MAUCOURT (start October 2015), Pauline CHAIGNAUD (2012-2016, co-tutelle Université de Strasbourg/ University of Bayreuth, German co-supervisor, S. Kolb), Emilie MULLER (2007-2011, co-supervisor S. Vuilleumier), Sandro ROSELLI (2006-2009, co-supervisor S. Vuilleumier), Christian PENNY (2005-2009, co-supervisor S. Vuilleumier), Hervé NICOLOFF (1997-2001, co-supervisor J.C. Hubert).

    • Of 33 final year Diploma and Master undergraduate students (3 months - 1 year each; Master diploma underlined)Alicia BOYON (2017), Sophia BERNHART-SCHOENFELDER (2016), Busra BICAKCI (2016), Bruno MAUCOURT (2015), Farah HAJJAR OUWAYED (2014), Panyu KUANG, Thomas SONNTAG (2014), Souad ALIOUA, Antoine NGUYEN (2013), Alexandre SCHAUB, Antoine PERRIER, Choé LUTZ (2012) Caroline ROSER, Kévin BAUMERT (2011), Carole PFISTER, Romain GASSER, Agustina LLANOS (2010), Elena IULIANI, Charles-Benjamin GEITNER (2009), Audrey GEISSLER, Matthieu LEOPOLD, Sophia EL HASSOUNI (2008), Lang ROMAIN (2007), Brunot SCHIRRET, Valérie SCHMUTZ (2006), Thomas JEAND’HEUR (2004), Cédric MALADAIN (2003), Tanja KRNJAJA (2002), Céline SCHLECHER (2001), Julien DELVILLE (2000), Virginie RINGAULT (1998), Hervé NICOLOFF (1997), Stéphane BOIVIN (1996)
  • Visits of foreign researchers (> 2 months)
    2008, S. EL HASSOUINI of Université Mohemmad V-Agdal, Rabat, Maroc
    2004, Jan MARTINUSSEN of Denmark Technical University
    2001, Tanja KRNJAJA of Belgrade University
    1994. Daniel OLUKOYA of National Institute for Medical Research, Lagos, Nigeria
  • Member of Dissertation Committees: PhD thesis or habilitation in France (10) and outside (3; Belgium; Denmark; South Africa)
  • Teaching: Lecturer  at University Paris-Saclay Master M2 (3h/year since 2015) Course on Plant Microbiota and Volatile Organic Compound Emissions; University of Strasbourg (12 h/year since 2001) Faculty of Pharmacy, Course on Genetics and Genomics of lactic acid bacteria
  • Service to University and CNRS
    • 2017-ongoing Nominated member of the Scientific comity ‘Action Thématique (AT) MicrobiEN’ CNRS
    • 2014, Member of the selection committee for Life Science Ph.D grant attribution
    • 2007-2008, Elected member of the scientific board (“conseil scientifique”) of Université Louis Pasteur Strasbourg, France
    • 2003-2007, Elected member of the administration board of direction (“conseil d’administration”) of Université Louis Pasteur Strasbourg, France
    • Occasional member of the Faculty recruitment committee, Faculty of Biology (Section 64)

Current and recent research support as a PI

  • 2015-2017, ANR/DFG (Deutsche Forschungsgemeinschaft) French-Germany international grant CHLOROfilter, Impact of microorganisms on the regulation of chloromethane emissions into the atmosphere (coordinator)
  • 2015-2016, Idex post-doctorant (Initiative d’excellence for future investments), Université de Strasbourg, Study of a prokaryotic ncRNA involved in the regulation of a pollutant biodegradation pathway
  • 2013-2014, INSU CNRS EC2CO (France) TOP-DCM, Adaptation of a microbial compartment of a multi-polluted topsoil in a microcosm exposed to dichloromethane
  • 2012-2015, PhD grant of the Région Alsace France for 18 months. Microbes as sinks of chloromethane – from model strains to soil communities
  • since 2012, MethyloScope platform for methylotrophic bacteria genome analysis (co-coordinator) (http://www.genoscope.cns.fr/agc/microscope)
  • 2011-ongoing, IbiSA-Genoscope, Large-scale DNA sequencing project (France) Deep RNA sequencing analysis of the Methylobacterium response to halogenated pollutants
  • 2008-2009, INSU CNRS Ec2co (France), HALOGEN1Cs- Functional study of an aquifer ecosystem contaminated with toxic C1 halogenic compounds

Honors and Awards

  • 2014, Received 6th, CNRS section 21 DR2 recruitment campaign
  • 2007, Fellowship, Cooperative Research Programme OCDE, Denmark
  • 2006, Prof. qualification (CNU Biochemistry and Molecular Biology) France
  • 1992, Received first, CNRS section 21 CR2 recruitment campaign
  • 1990-1991, Postdoctoral fellowship, Emory University in Atlanta USA, NHI funds USA
  • 1986-1990, PhD grant, Graduate School for Life and Medical Sciences of the University Louis Pasteur, recruitment campaign 1986

List of publications


Bibi-Triki, S., Husson, G., Maucourt, B., Vuilleumier, S., Carapito, C., Bringel, F.  (2018) N-terminome and proteogenomic analysis of the Methylobacterium extorquens DM4 reference strain for dichloromethane utilization. J. Proteomics. 179, 131-139.

Jaeger, N., Besaury, L., Röhling, A.N., Koch, F., Delort, A.-M., Gasc, C., Greule, M.,  Kolb, S., Nadalig, T., Peyret, P., Vuilleumier, S., Amato, P., Bringel, F.,  Keppler, F. (2018) Chloromethane formation and degradation in the fern phyllosphere. Sci. Total Environ. 634, 1278-1287.

Jaeger, N., , Besaury, L., Kröber, E., Delort, A-M, Greule, M., Lenhart, K., Nadalig, T., Vuilleumier, S., Amato, P., Kolb, S., Bringel, F. & Keppler, F. (2018) Chloromethane degradation in soils - a combined microbial and two-dimensional stable isotope approach. J. Environ.Qual. 47, 254-262.

Bringel, F. & Couée, I. (2017) Plant-pesticide interactions and the global chloromethane budget. Trends Plant Sci.23(2), 95-99.


Farhan Ul Haque, M., Besaury, L., Nadalig, T., Bringel, F., Mutterer, J., Schaller, H. & Vuilleumier, S. (2017) Correlated production and consumption of chloromethane in the Arabidopsis thaliana phyllosphere. Scientific Reports 7, 17589.

Bringel, F. & Vuilleumier, S. (2017). Metabolic regulation: A master role for ribulose-1,5-bisphosphate in one-carbon assimilation. Curr. Biol. 27, R1127-R1129.

Chaignaud, P., Maucourt, B., Weiman, M., Alberti, A., Kolb, S., Cruveiller, S., Vuilleumier, S. & Bringel, F. (2017). Genomic and transcriptomic analysis of growth-supporting dehalogenation of chlorinated methanes in Methylobacterium. Front. Microbiol. 8:1600.

Bringel, F., Postema, C.P., Mangenot, S., Bibi-Triki, S., Chaignaud, P., Farhan Ul Haque, M., Gruffaz, C., Hermon, L., Louhichi, Y., Maucourt, B., Muller, E.E.L., Nadalig, T., Lajus, A., Rouy, Z., Médigue, C., Barbe, V., Janssen, D.B. & Vuilleumier, S. (2017) Genome sequence of the dichloromethane-degrading bacterium Hyphomicrobium sp. strain GJ21. Genome Announc. 5, art. 00622-17

Frindte, K., Kalyuzhnaya, M., Bringel, F., Dunfield, P., Jetten, M., Khmelenina, V., Klotz, M., Murrell, C., Op Den Camp, H., Sakai, Y., Semrau, J., Shapiro, N., Dispirito, A., Stein, L., Svenning, M., Trotsenko, Y., Vuilleumier, S., Woyke, T. & Knief, C. (2017) Draft genome sequences of two gammaproteobacterial methanotrophs isolated from rice ecosystems. Genome Announc. 5, art. 00526-17

Bradley, A. S., Swanson, P.K., Muller, E. E. L., Bringel, F., Carroll, S. M., Pearson, A., Vuilleumier, S., Marx, C. J. (2017). Hopanoid-free Methylobacterium extorquens DM4 overproduces carotenoids and has widespread growth impairment. PLoS ONE 12 (3):e0173323. doi: 10.1371/journal.pone.0173323


Michener, J.K., Vuilleumier, S., Bringel, F., Marx, C.J (2016). Transfer of a catabolic pathway for chloromethane in Methylobacterium strains highlights different limitations for growth with chloromethane or with dichloromethane. Front. Microbiol. 7:1116.

Flynn, J., Hirayama, H., Sakai, Y., Dunfield, PF., Klotz, MG., Knief, C., Op den Camp, HJ., Jetten, MJM., Khmelenina, VN., Trotsenko, YA., Murrell, JC., Semrau, JD., Svenning, MM., Stein, LY., Kyrpides, N., Shapiro, N., Woyke, T., Bringel, F., Vuilleumier, S., DiSpirito, AA., Kalyuzhnaya, MG. (2016). Draft genomes of gammproteobacterial methanotrophs isolated from marine ecosystems. Genome Announc. 4(1):e01629-15.

Alioua, S., Abdi, A., Fhoula, I., Bringel, F., Boudabous, A., Ouzari, I. H. (2016) Diversity of vaginal lactic acid bacterial microbiota in 15 Algerian pregnant women with and without bacterial vaginosis by using culture independent method. J. Clin. Diagn. Res. 10(9):DC23-DC27.


Flynn, J., Hirayama, H., Sakai, Y., Dunfield, PF., Klotz, MG., Knief, C., Op den Camp, HJ., Jetten, MJM., Khmelenina, VN., Trotsenko, YA., Murrell, JC., Semrau, JD., Svenning, MM., Stein, LY., Kyrpides, N., Shapiro, N., Woyke, T., Bringel, F., Vuilleumier, S., DiSpirito, AA., Kalyuzhnaya, MG. (2015). Draft genomes of gammproteobacterial methanotrophs isolated from marine ecosystems. Genome Announc. 4(1):e01629-15.

Penny, C., Gruffaz, C., Nadalig, T., Cauchie, H.-M., Vuilleumier, S. & Bringel, F. (2015) Tetrachloromethane-degrading bacterial enrichment cultures and isolates from a contaminated aquifer. Microorganisms 3, 327-343.

Sharp, C., Smirnova, A., Kalyuzhnaya, M., Bringel, F., Hirayama, H., Jetten, M., Khmelenina, V., Klotz, M., Knief, C., Kyrpides, N., Op den Camp, H., Reshetnikov, A., Sakai, Y., Shapiro, N., Trotsenko, Y., Vuilleumier, S., Woyke, T. & Dunfield, P. (2015) Draft genome sequence of the moderately halophilic methanotroph, Methylohalobius crimeensis strain 10Ki. Genome Announc. 3(3):e00644-15

Hamilton, R., Kits, J., Ramonovskay, V., Rozova, ON., Yurimoto, H., Iguchi, H., Khmelenina, VN., Sakai, Y., Dunfield, PF., Klotz, MG., Knief, C., Op den Camp, HJM., Jetten, MSM., Bringel, F., Vuilleumier, S., Svenning, MM., Shapiro, N., Woyke, T., Trotsenko, YA., Stein, LY. & Kalyuzhnaya, MG. (2015) Draft genomes of gammaproteobacterial methanotrophs isolated from terrestrial ecosystems. Genome Announc. 3(3):e00515-15

Bringel, F. & Couée I (2015). Pivotal roles of phyllosphere microorganisms at the interface between plant functioning and atmospheric trace gas dynamics. Front. Microbiol. 6:486.

Bringel, F. & Couée, I. (2015) Les microbiomes de la phyllosphère. In La métagénomique : Développements actuels et futures applications, Editors Champomier-Vergès, M.F. & Zagorec, M., Editions Quae, Collection Savoir faire, Chapitre 8, 97-108. ISBN 9782759222933.


Michener, J.K., Camargo Neves, A.A., Vuilleumier, S., Bringel, F. & Marx, C.J. (2014). Effective use of a horizontally-transferred pathway for dichloromethane catabolism requires post-transfer refinement. eLife 2014; 3:04279.

Nadalig, T., Greule, M., Bringel, F., Keppler, F. & Vuilleumier, S. (2014) Probing the diversity of chloromethane-degrading bacteria by comparative genomics and isotopic fractionation. Front. Microbiol. 5: 523

Boguta, A.M., Bringel, F., Martinussen, J. & Jensen P.R. (2014) Screening of Lactic Acid Bacteria for their potential as microbial cell factories for bioconversion of lignocellulosic feedstocks. Microb. Cell Fact. 13, 97.

Gruffaz, C., Muller, E.E.L., Louhichi-Jelail, Y., Nelli, Y.R., Guichard, G. & Bringel, F. (2014) Genes of the N-methylglutamate pathway are essential for growth of Methylobacterium extorquens DM4 with monomethylamine. Appl. Environ. Microbiol. 80, 3541-3550.

Michener, J., Vuilleumier, S., Bringel, F. & Marx, C. (2014) Phylogeny poorly predicts the utility of a challenging horizontally-transferred gene in Methylobacterium strains. J. Bacteriol. 196, 2101-2107.


Kalyuzhnaya, M.G., Yang, S., Rozova, O.N., Smalley, N.E., Clubb, J., Lamb, A., Nagana Gowda, G.A., Raftery, D., Fu, Y., Bringel, F., Vuilleumier, S., Trotsenko, Y.A., Beck, D., Khmelenina, V.N. & Lidstrom, M.E. (2013) Highly efficient methane biocatalysis revealed in a methanotrophic bacterium. Nature Communications 4, 2785.

Nadalig, T., Greule, M., Bringel, F., Vuilleumier, S. & Keppler, F. (2013) Hydrogen and carbon isotope fractionation during degradation of chloromethane by methylotrophic bacteria. MicrobiologyOpen 2 (6), 893-900.

Farhan Ul Haque, MF., Nadalig, T., Bringel, F., Schaller, H. & Vuilleumier, S. (2013) A fluorescence-based bacterial bioreporter for the specific detection of methyl halide emissions in the environment. Appl. Environ. Microbiol. 79, 6561-6567.

Khmelenina, V.N., Beck, D., Munk, C., Davenport, K., Daligault, H., Erkkila, T., Goodwin, L., Gu, W., Lo, C-C., Scholz, M., Teshima, H., Xu, Y., Chain, P., Bringel, F., Vuilleumier, S., DiSpirito, A., Dunfield, P., Jetten, M.S.M., Klotz, M.G., Knief, C., Murrell, J.C., Op den Camp, H.J.M., Sakai, Y., Semrau, S., Svenning, M., Stein, L.Y., Trotsenko, Y.A. & Kalyuzhnaya, M.G. (2013) Draft genome sequence of Methylomicrobium buryatense 5G, a haloalkaline-tolerant methanotrophic bacterium. Genome Announc. 1(4):e00053-13.

Kits, K., Kalyuzhnaya, M., Klotz, M., Jetten, M., Op den Camp, H., Vuilleumier, S., Bringel, F., DiSpirito, A., Murrell, C., Bruce, D., Cheng, J-F., Copeland, A., Goodwin, L., Hauser, L., Lajus, A., Land, M., Lapidus, A., Lucas, S., Médigue, C., Pitluck, S., Woyke, T., Zeytun, A. & Stein, L. (2013) Genome sequence of the obligate Gammaproteobacterial methanotroph Methylomicrobium album strain BG8. Genome Announc. 1(2):e00170-13.

Roselli, S., Nadalig, T., Vuilleumier, S. & Bringel, F. (2013) The 380 kb pCMU01 plasmid encodes chloromethane utilization genes and redundant genes for vitamin B12- and tetrahydrofolate-dependent chloromethane metabolism in Methylobacterium extorquens CM4: A proteomic and bioinformatics study. PLoS ONE 8(4), e56598.


Marx, C.J., Bringel, F., Chistoserdova, L., Moulin, L., Farhan Ul Haque, M., Fleischman, D.E., Gruffaz, C., Jourand, P., Knief, C., Lee, M-C., Muller, E.E.L., Nadalig, T., Peyraud, R., Roselli, S., Russ, L., Goodwin, L.A., Ivanova, N., Kyrpides, N., Lajus, A., Land, M.L., Médigue, C., Mikhailova, N., Nolan, M., Woyke, T., Stolyar, S., Vorholt, J.A. & Vuilleumier, S. (2012). Complete genome sequences of six strains of the genus Methylobacterium. J. Bacteriol. 194, 4746-4748.

Hamon, E., Horvatovitch, P., Bisch, M., Bringel, F., Marchioni, E., Aoude-Werner, D. &  Ennahar, S. (2012). Investigation of biomarkers of bile tolerance in Lactobacillus casei using comparative proteomics. J. Proteome Res. 111, 109-118.

Vuilleumier, S., Khmelenina, V.N., Bringel, F., Reshetnikov, A.S., Lajus, A., Mangenot, S., Rouy, Z., Op den Camp, H.J.M., Jetten, M.S.M., DiSpirito, A.A., Dunfield, P., Klotz, M.G., Semrau, J.D., Stein, L.Y., Barbe, V., Médigue, C., Trotsenko Y.A. & Kalyuzhnaya, M.G. (2012). Genome sequence of the haloalkaliphilic methanotrophic bacterium Methylomicrobium alcaliphilum 20Z. J. Bacteriol. 194, 551-552.


Svenning, M.M., Hestnes, A.G., Wartiainen, I., Stein, L.Y., Klotz, M.G., Kalyuzhnaya, M.G., Spang, A., Bringel, F., Vuilleumier, S., Lajus, A., Médigue, C., Bruce, D.C., Cheng, J.F., Goodwin, L., Ivanova, N., Han, J., Han, C.S., Hauser, L., Held, B., Land, M.L., Lapidus, A., Lucas, S., Nolan, M., Pitluck, S. & Woyke, T. (2011). Genome sequence of the Arctic Methanotroph Methylobacter tundripaludum SV96. J. Bacteriol. 193, 6418-6419

Vuilleumier, S., Nadalig, T., Farhan Ul Haque, M., Magdelenat, G., Lajus, A., Roselli, S., Muller, E.E.L., Gruffaz, C., Barbe, V., Médigue, C. & Bringel, F. (2011) Complete genome sequence of the chloromethane-degrading strain Hyphomicrobium sp. strain MC1. J. Bacteriol. 193, 5035-5036

Kittichotirat, W., Good, N., Hall, R., Bringel, F., Lajus, A., Médigue, C., Smalley, N., Beck, D., Bumgarner, R., Vuilleumier, S. & Kalyuzhnaya, M.G. (2011). Genome sequence of Methyloversatilis universalis FAM5T, a methylotrophic representative of the order Rhodocyclales. J. Bacteriol. 193, 4541-4542.

Muller, E., Hourcade, E., Louhichi-Jelail, Y., Hammann, P., Vuilleumier, S. & Bringel, F. (2011) Functional genomics of dichloromethane utilisation in Methylobacterium extorquens DM4. Environ. Microbiol. 13, 2518-2535

Nadalig, T., Farhan Ul Haque, M., Roselli, S., Schaller, H., Bringel, F. & Vuilleumier, S. (2011) Detection and isolation of chloromethane-degrading bacteria from the Arabidopsis thaliana phyllosphere, and characterization of chloromethane utilisation genes. FEMS Microbiol. Ecol. 77, 438-448.

Muller, E., Bringel, F. & Vuilleumier, S. (2011) Dichloromethane-degrading bacteria in the genomic age. Res Microbiol. 162, 869-876.

Stein, L.Y., Bringel, F., DiSpirito, A.A., Han, S., Jetten, M.S.M., Kalyuzhnaya, M.G., Kits, K.D., Klotz, M.G., Op den Camp, H.J.M., Semrau, J.D., Vuilleumier, S., Bruce, F., Cheng, J.F., Copeland, A., Davenport, K.W., Goodwin, L., Han, S., Hauser, L., Lajus, A., Land, M.L., Lapidus, A., Lucas, S., Médigue, C., Pitluck, S. & Woyke, T. (2011). Genome sequence of the methanotrophic Alphaproteobacterium, Methylocystis sp. Rockwell (ATCC 49242). J. Bacteriol. 193, 2668-2669.

Hamon, E., Horvatovich P., Izquierdo E., Bringel, F., Marchioni, E., Aoude-Werner, D. & Ennahar, S. (2011) Comparative proteomic analysis of Lactobacillus plantarum for the identification of key proteins in bile tolerance. BMC Microbiology. 11, 63.

Imfeld, G., Bringel, F. & Vuilleumier, S. (2011) Bacterial tolerance in contaminated soils: potential of the PICT approach in microbial ecology. In: Tolerance to Environmental Contaminants (Amiard-Triquet C, Rainbow PS, Roméo M), CRC Press, Boca Raton, Chapitre 14, 335-364.


Stein, L.Y., Semrau, J.D., DiSpirito, A.A., Murrell, J.C., Vuilleumier, S., Kalyuzhnaya, M.G., Op den Camp, H.J.M., Bringel, F., Bruce, F., Cheng, J.F., Copeland, A.,  Goodwin, L., Han, S., Hauser, L., Jetten, M.S.M., Lajus, A., Land, M.L., Lapidus, A., Lucas, S., Médigue, C., Pitluck, S., Woyke, T., Yoon, S., Zeytun, A. & Klotz, M.G. (2010) Genome sequence of the obligate methanotroph, Methylosinus trichosporium strain OB3b. J. Bacteriol. 192, 6497-6498

Penny, C., Nadalig, T., Alioua, M., Gruffaz, C., Vuilleumier, S. & Bringel, F. (2010) Coupling of denaturing high-performance liquid length chromatography and terminal restriction fragment length polymorphism with precise fragment size calling for microbial community profiling and characterization. Appl. Environ. Microbiol. 76, 648-651.

Couée, I & Bringel, F. (2010) Expanding importance of mRNA expression in understanding stress and stress responses. J. Theor. Biol. 266(3), 479-482

Penny, C., Vuilleumier, S. & Bringel, F. (2010) Microbial degradation of tetrachloromethane : mechanisms and perspectives for bioremediation. FEMS Microbiol. Ecol. 74, 257-275