AARS Online is an interactive Wikipedia-like tool curated by an international consortium of aminoacyl-tRNA synthetase (aaRS) experts. Accessible at www.aars.online, it is a free resource to delve into the world of aaRSs, key players of the mRNA translation process. AARS Online systematizes existing…
Autors : Solène Zuttion, Bruno Senger, Chiranjit Panja, Sylvie Friant, Róża Kucharczyk and Hubert Dominique Becker Photo : ©Jaime-Olivares
Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma. doi.org/10.1038/s41556-024-01439-2 Transfer RNA dynamics contribute to cancer development through regulation of codon-specific messenger RNA translation. Specific aminoacyl-tRNA synthetases can either promote or suppress…
Natural proteome diversity links aneuploidy tolerance to protein turnover. Julia Muenzner, Pauline Trébulle, Federica Agostini, Henrik Zauber, Christoph B. Messner, Martin Steger, Christiane Kilian, Kate Lau, Natalie Barthel, Andrea Lehmann, Kathrin Textoris-Taube, Elodie Caudal, Anna-Sophia Egger,…
Pan-transcriptome reveals a large accessory genome contribution to gene expression variation in yeast. Élodie Caudal, Victor Loegler, Fabien Dutreux, Nikolaos Vakirlis, Élie Teyssonnière, Claudia Caradec, Anne Friedrich, Jing Hou, Joseph Schacherer. Nature Genetics. 2024. doi:…
Species-wide quantitative transcriptomes and proteomes reveal distinct genetic control of gene expression variation in yeast. Elie M Teyssonnière, Pauline Trébulle, Julia Muenzner, Joseph Schacherer. PNAS. 2024. doi:10.1073/pnas.2319211121 Gene expression varies between individuals and corresponds…
Absence of chromosome axis protein recruitment prevents meiotic recombination chromosome-wide in the budding yeast Lachancea kluyveri. Sylvain Legrand, Asma Saifudeen, Hélène Bordelet, Julien Vernerey, Arnaud Guille, Amaury Bignaud, Agnès Thierry, Laurent Acquaviva, Maxime Gaudin, Aurore Sanchez,…
Diallel panel reveals a significant impact of low-frequency genetic variants on gene expression variation in yeast. Andreas Tsouris, Gauthier Brach, Anne Friedrich, Jing Hou, Joseph Schacherer. Mol Syst Biol. 2024. doi:10.1038/s44320-024-00021-0 Unraveling the genetic sources of gene expression…
Translation variation across genetic backgrounds reveals a post-transcriptional buffering signature in yeast. Elie M Teyssonniere, Yuichi Shichino, Mari Mito, Anne Friedrich, Shintaro Iwasaki, Joseph Schacherer. Nucleic Acids Research. 2024. doi:10.1093/nar/gkae030 Gene expression is known to…
Non-additive genetic components contribute significantly to population-wide gene expression variation. Andreas Tsouris, Gauthier Brach, Joseph Schacherer, Jing Hou. Gene expression variation, an essential step between genotype and phenotype, is collectively controlled by local (cis) and distant (tr…
Telomere-to-telomere assemblies of 142 strains characterize the genome structural landscape in Saccharomyces cerevisiae. Samuel O’Donnell, Jia-Xing Yue, Omar Abou Saada, Nicolas Agier, Claudia Caradec, Thomas Cokelaer, Matteo De Chiara, Stéphane Delmas, Fabien Dutreux, Téo Fournier, Anne Friedrich,…
Copy number variation alters local and global mutational tolerance. Grace Avecilla, Pieter Spealman, Julia Matthews, Elodie Caudal, Joseph Schacherer, David Gresham. Copy number variants (CNVs), duplications and deletions of genomic sequences, contribute to evolutionary adaptation but can also…
Impact of the acquired subgenome on the transcriptional landscape in Brettanomyces bruxellensis allopolyploids. Arthur Jallet, Anne Friedrich, Joseph Schacherer. G3 Genes|Genomes|Genetics. 2023. doi:10.1093/g3journal/jkad115 Gene expression variation can provide an overview of the changes in…
Contrasting genomic evolution between domesticated and wild Kluyveromyces lactis yeast populations. Anne Friedrich, Jean-Sébastien Gounot, Andreas Tsouris, Claudine Bleykasten, Kelle Freel, Claudia Caradec, Joseph Schacherer. Genome Biology and Evolution. 2023. doi:10.1093/gbe/evad004 The process…
Lessons from the meiotic recombination landscape of the ZMM deficient budding yeast Lachancea waltii. Fabien Dutreux, Abhishek Dutta, Emilien Peltier, Sabrina Bibi-Triki, Anne Friedrich, Bertrand Llorente, Joseph Schacherer. PLoS Genet. 2023. doi:10.1371/journal.pgen.1010592 Meiotic recombination…
A new genome-wide method that marries classical enzymatic kinetics, deep sequencing, and mathematical modelling - CoLoC-seq - has been created in the MITO team and successfully applied to human mitochondria to tell resident RNAs from contaminants.
Theoretical and mathematical biology paper about hub-centred RNA-protein networks
Loss of heterozygosity spectrum depends on ploidy level in natural yeast populations. Abhishek Dutta, Fabien Dutreux, Joseph Schacherer. Molecular Biology and Evolution. 2022. doi:10.1093/molbev/msac214 The appearance of genomic variations such as loss of heterozygosity (LOH) has a significant…
