Viola Mazzoleni, Gaelle Zimmermann-Meisse, Anna Smirnova, Ivan Tarassov, Gilles Prévost (2020) Staphylococcus aureus Panton-Valentine Leukocidin triggers an alternative NETosis process targeting mitochondria. FASEB J (in press)

Karine Auré, Guillemette Fayet, Ivan Chicherin, Benoit Rucheton, Sandrine Filaut, Anne-Marie Heckel, Julie Eichler, Florence Caillon, Yann Péréon, Nina Entelis, Ivan Tarassov, Anne Lombès (2020) A homoplasmic mitochondrial tRNAPro mutation causing exercise-induced muscle swelling and fatigue. Neurology: Genetics; DOI:

S. Summer, A. Smirnova, A. Gabriele, U. Toth, A. M. Fasemore, K. U. Forstner, L. Kuhn, J. Chicher, P. Hammann, G. Mitulovic, N. Entelis, I. Tarassov, W. Rossmanith, A. Smirnov, YBEY is an essential biogenesis factor for mitochondrial ribosomes. Nucleic Acids Research, Volume 48, Issue 17, 25 September 2020, Pages 9762–9786.

Smirnova Anna, Richert Ludovic, SmirnovAlexandre, Mély Yves, Tarassov Ivan. "Suborganellar localisation of mitochondrial proteins and transcripts in human cells", in: Methods in Molecular Biology, Springer Protocols. Mitochondrial Medicine, 2nd edition, V. Weissig, M. Edeas, Editors. Humana Press, Springer New York Heidelberg Dordrecht London, 2020, in press.

Ilya Dovydenko, Mariya Meschaninova, Anne-Marie Heckel, Ivan Tarassov, Alya Venyaminova and Nina Entelis. "Lipophilic conjugates for carrier-free delivery of RNA importable into human mitochondria", in: Methods in Molecular Biology, Springer Protocols. Mitochondrial Medicine, 2nd edition, V. Weissig, M. Edeas, Editors. Humana Press, Springer New York Heidelberg Dordrecht London, 2020, in press.


D. Jeandard, A. Smirnova, I. Tarassov, E. Barrey, A. Smirnov, N. Entelis (2019) Import of non-coding RNAs into human mitochondria: a critical review and emerging approaches. Cells 8, 286; doi:10.3390/cells8030286


Melanie Meyer, Helene Walbott, Vincent Olieric, Jiro Kondo, Maria Costa and Benoit Masquida (2019) Conformational adaptation of UNCG loops upon crowding. RNA; in press


PA Kamenski, IA Krasheninnikov, I. Tarassov (2019) 40 years of studying RNA import into mitochondria: from basic mechanisms to gene therapy strategies. Molecular Biology v53, N°6 924-932. 


R Loutre, AM Heckel, A Smirnova, N Entelis, I Tarassov (2018) Can mitochondrial DNA be CRISPRized: pro and contra. IUBMB Life, Sep 5. doi: 10.1002/iub.1919. [Epub ahead of print]


R. Loutre, AM Heckel, D Jeandard, I Tarassov, N Entelis (2018) "Anti-replicative recombinant 5S rRNA molecules can modulate the mtDNA heteroplasmy in a glucose-dependent manner" PLOS ONE


Smirnov A., Schneider C., Hor J., Vogel J. (2017) "Discovery of new classes and global RNA-binding proteins." Current Opinion in Microbiology 39, 152-160.

Namer, L.S., Osman, F., Banai, Y., Masquida, B., Jung, R., and Kaempfer, R. (2017) "An Ancient Pseudoknot in TNF-alpha Pre-mRNA Activates PKR, Inducing eIF2alpha Phosphorylation that Potently Enhances Splicing." Cell reports 20, 188-200.

Chicherin IV, Levitsky SA, Krasheninnikov IA, Tarassov I, Kamenski P (2017) “The prospects of gene therapy of for mitochondrial diseases: can’t we do without CRISPR/Cas9?” Bulletin of RSMU 3, 2017, 43-47.

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M. V. Baleva, M. Meyer, N. Entelis, I. Tarassov, P. Kamenski, and B. Masquida (2017) "Factors Beyond Enolase 2 and Mitochondrial Lysyl-tRNA Synthetase Precursor Are Required for tRNA Import into Yeast Mitochondria" Biochemistry (Moscow) Vol 82, 1324-1335.


Angulo J, Ulryck N, Deforges J, Chamond N, Lopez-Lastra M, Masquida B, Sargueil B. (2016) LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex. Nucleic Acids Res., 44, 1309-1325.


I. Dovydenko, A. Veniaminova, D. Pyshnyi, I. Tarassov, N. Entelis (2016) Modifications in therapeutic oligonucleotides improving the delivery. In: Nucleic Acids Modifications, Springer series (J. Barciszewski, Ed.), pp. 319-337.

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E.V. Smirnova, I.V. Chicherin, M.V. Baleva, N. Entelis, I. Tarassov, P.A. Kamenski (2016) PreMsk1p purification and tRNA import. Biochemistry (Moscow), Vol. 81, N°10, 1081-1088.


Meyer, M., and Masquida, B. (2016). Polyacrylamide Gel Electrophoresis for Purification of Large Amounts of RNA. Methods in molecular biology 1320, 59-65.


Andersen, K.L., Beckert, B., Masquida, B., Johansen, S.D., and Nielsen, H. (2016). Accumulation of Stable Full-Length Circular Group I Intron RNAs during Heat-Shock. Molecules 21, 1541-1558.


Fernandez-Millan, P., Schelcher, C., Chihade, J., Masquida, B., Giege, P., and Sauter, C. (2016). Transfer RNA: From pioneering crystallographic studies to contemporary tRNA biology. Archives of biochemistry and biophysics 602, 95-105.


I. Dovydenko, I. Tarassov,  A. Venyaminova, N. Entelis (2015) Method of carrier-free delivery of therapeutic RNA importable into human mitochondria: lipophilic conjugates with cleavable bonds. Biomaterials (in press)

I. Dovydenko, A-M Heckel, Y. Tonin, A. Gowher, A. Venyaminova, I. Tarassov and N. Entelis (2015) Mitochondrial targeting of recombinant RNA. Methods in Mol. Biol (MiMB series). 1265: 209-225.

M. Baleva, A. Gowher, P. Kamenski, I. Tarassov, N., Entelis, B. Masquida (2015). A moonlighting human protein is involved in mitochondrial import of tRNA. Int. J. Mol. Sci. (IJMS) 16(5): 9354-9367.


I. Tarassov, N. Entelis (2014) New Vector for Therapy of Mitochondrial Disease. Patent US 62/011,755.

Tonin Y, Entelis N (2014) Mitochondrial DNA diseases and therapeutic strategies [Article in French] Med Sci (Paris); 30(12):1101-9. doi:10.1051/medsci/20143012013. Epub 2014 Dec 24.

Kondo J., Sauter C. and Masquida B. (2014)  RNA Crystallization. In : Handbook of RNA biochemistry: Second, Completely Revised and Enlarged Edition (Hartmann, R.K., Bindereif, A., Schön, A., Westhof, E., eds.) pp. 481-498. Wiley-VCH.

Meyer M, Nielsen H, Oliéric V, Roblin P, Johansen SD, Westhof E, Masquida B. (2014) Speciation of a group I intron into a lariat capping ribozyme. Proc. Natl. Acad. Sci. USA, 111(21): 7659-64.

Y. Tonin, A.-M. Heckel, M. Vysokikh, I. Dovydenko, M. Meschaninova,  A. Rötig, A. Munnich, A. Venyaminova, I. Tarassov, N. Entelis (2014) Modelling of antigenomic therapy of mitochondrial diseases by mitochondrially addressed RNA targeting a pathogenic point mutation in mtDNA. J. Biol. Chem., 289(10) 13323-34.

Maréchal-Drouard L, Sissler M, Tarassov I. (2014) Mitochondria: An organelle for life. Biochimie, (in press) doi: 10.1016/j.biochi.2014.02.003. 100:1-2.

Tonin Y, Heckel AM, Dovydenko I, Meschaninova M, Comte C, Venyaminova A, Pyshnyi D, Tarassov I, Entelis N. (2014) Characterization of chemically modified oligonucleotides targeting a pathogenic mutation in human mitochondrial DNA. Biochimie 100: 192-9.

Meyer, M., Masquida, B. (2014) Cis-Acting 5' Hammerhead ribozyme optimization for in vitro transcription of highly structured RNAs. Methods in Molecular Biology, 1086, 21-40.


I. Tarassov, I. Chicherin, Y. Tonin, A. Smirnov, P. Kamenski, N. Entelis (2013) Mitochondrial targeting of RNA and mitochondrial translation. In: A.-M. Duchene (ed.), Translation in mitochondria and other organelles, Springer-Verlag Berlin Heidelberg, pp.85-107

A. Gowher, A. Smirnov, I. Tarassov, N. Entelis (2013) Induced tRNA import into human mitochondria: implication of a host aminoacyl-tRNA-synthetase. PLoS ONE, Jun 14;8(6):e66228. doi: 10.1371/journal.pone.0066228.

C. Comte, Y. Tonin, A.-M. Heckel-Mager, A. Boucheham, A. Smirnov, K. Auré, A. Lombès, R. P. Martin, N. Entelis,I. Tarassov (2013) Mitochondrial targeting of recombinant RNAs modulates the level of a heteroplasmic mutation in human mitochondrial DNA associated with Kearns Sayre Syndrome. Nucleic Acids Res., 41(1):418-33.



V. Vedrenne, A. Gowher, P. De Lonlay, P. Nitschke, V. Serre, N. Boddaert, C. Aaltuzarra, A.-M. Mager-Heckel, F. Chretien, N. Entelis, A. Munnich, I. Tarassov, A. Rötig (2012) Mutation in PNPT1, which encodes a polyribonucleotide nucleotidyltransferase, impairs RNA import into mitochondria and causes respiratory chain deficiency. Am. J. Hum. Genetics, 2012 Nov 2;91(5):912-8.

S. Kanga, D. Bernard, A.-M. Mager-Heckel, Zo. Erpapazoglou, F. Mattiroli, T. K. Sixma, S. Léon, D. Urban-Grimal, I. Tarassov and R. Haguenauer-Tsapis (2012) A deubiquitylating complex required for neosynthesis of a yeast mitochondrial ATP synthase subunit. PLoS One. 7(6), e38071.

E. V. Smirnova, V. A. Lakunina, I. Tarassov, I. A. Krasheninnikov, and P. A. Kamenski (2012) Noncanonical Functions of Aminoacyl-tRNA Synthetases. Biochemistry (Moscow) 77 (1), 21-33.


Atkinson GC, Kuzmenko A, Kamenski P, Vysokikh MY, Lakunina V, Tankov S, Smirnova E, Soosaar A, Tenson T, Hauryliuk V. (2012) Evolutionary and genetic analyses of mitochondrial translation initiation factors identify the missing mitochondrial IF3 in S. cerevisiae. Nucleic Acids Res. 40 (13), 6122-6134.


R. Belostotsky, Y. Frishberg, N. Entelis (2012) Human mitochondrial tRNAquality control in health and disease: a channeling mechanism? RNA Biology 9(1), 33-39.






A. Kuzmenko, S. Tankov, B. P. English, I. Tarassov, T. Tenson, P. Kamenski, J. Elf, V. Hauryliuk (2011). Single molecule tracking fluorescence microscopy reveals highly dynamic but confined nature of Tom40 movement. Sci. Reports (Nature publishing group, npg), 1, e195, DOI: doi:10.1038/srep00195.


O. Karicheva, O. Kolesnikova, T. Schirtz, M. Vysokikh, A.-M. Mager-Heckel, A. Lombès, A. Boucheham, I. Krasheninnikov, R. P. Martin, N. Entelis and I. Tarassov (2011) Correction of the consequences of mitochondrial 3243A>G mutation in the MT-TL1 gene causing the MELAS syndrome by tRNA import into mitochondria. Nucleic Acids Res 39 (18) 8173-8186.


A. Smirnov, N. Entelis, R. Martin, I. Tarassov (2011) Mitochondrial import of 5S rRNA in human cells: role of the MRP-L18 protein and biological significance. Genes & Dev. 25 (12) 1289-1305.


A. Smirnov, C. Comte, V. Addis, A.-M. Mager-Heckel, I. Krasheninnikov,  R. Martin, N. Entelis, I. Tarassov (2010) Mitochondrial enzyme rhodanese is essential for 5S ribosomal RNA import into human mitochondria. J. Biol. Chem. (in press).


P. Kamenski, E. Smirnova, O. Kolesnikova, I. Krasheninnikov, R. P. Martin, N. Entelis, I. Tarassov (2010) tRNA mitochondrial import in yeast: mapping of the import determinants in the carrier protein, the precursor of mitochondrial lysyl-tRNA synthetase. Mitochondrion 10, 284-293.


O. Kolesnikova, H. Kazakova, C. Comte, S. Steinberg, P. Kamenski, S. Steinberg, R. Martin, I. Tarassov, N. Entelis (2010) Selection of RNA aptamers imported into yeast and human mitochondria. RNA 16, 926-941.


Frenchin M, Kern D, Martin RP, Becker HD, Senger B. (2010) Arc1p: anchoring, routing, coordinating. FEBS lett. 584, 427-433.



A. Zeharia, A. Shaag, O. Pappo, A.-M. Mager-Heckel, A. Saada, M. Beinat, O. Karicheva, H. Mandel, N. Ofek, R. Segel, D. Marom , A. Rötig, I. Tarassov, O. Elpeleg (2009) Acute liver failure of infancy is caused by mutations in the TRMU gene. Am J Hum Genetics, 85, 401-407.


Frenchin M, Senger B, Brayé M, Kern D, Martin RP, Becker HD (2009) Yeast mitochondrial Gln-tRNA(Gln) is generated by a GatFAB-mediated transamidation pathway involving Arc1p-controlled subcellular sorting of cytosolic GluRS. Genes Dev.  23, 1119-30.



A. Smirnov, I. Tarassov, A.-M. Mager-Heckel, M. Letzelter, R. P. Martin, I. Krasheninnikov and N. Entelis (2008) Two distinct structural elements of 5S rRNA are needed for its import into human mitochondria RNA, 14, 749-759.


A. Smirnov, N. Entelis, I. Krasheninnikov, R. P. Martin, I. Tarassov,  (2008) Specific Features of 5S rRNA structure - its interactions with macromolecules and possible functions. Biochemistry (Moscow), 73, 1418-1437.



Mager-Heckel, A.-M., Brandina, I., Kamenski, P., Entelis, N., Martin, R.P., Tarassov, I. (2007) Methods of analysis of tRNA import into human mitochondria. In: "Mitochondria: Practical Protocols" (Leister D., Herrmann J., eds.); Methods in Molecular Biology, Humana Press (NJ, USA), vol. 372, pp 235-354.

Kamenski, P., Vinogradova E., Krasheninnikov, I., Tarassov, I. (2007) Directed import of macromolecules into mitochondria. Molecular Biology, 41, 187-202.


Pierre Rustin, Howard T. Jacobs, A. Dietrich, R. N. Lightowlers, I. Tarassov, M. Corral-Debrinski (2007) Adresser du matériel allogène dans le compartiment mitochondrial : Des outils nouveaux pour mieux comprendre la physiologie mitochondriale et une perspective pour la thérapie. Med Sci (Paris) 23, 519-525.


Kamenski, P., Kolesnikova, O., Jubenot, V., Entelis, N., Krasheninnikov, I., Martin, R.P., Tarassov, I. (2007). Evidence for an adaptation mechanism of mitochondrial translation via tRNA import from the cytosol. Molecular Cell 26, 625-637.


Simon Edvardson, Avraham Shaag, Olga Kolesnikova, John Moshe Gomori, Ivan Tarassov, Tom Einbinder, Ann Saada, Orly Elpeleg (2007) Deleterious mutation in the mitochondrial arginyl-tRNA synthetase gene is associated with ponto-cerebellar hypoplasia. Am J Hum Genetics, 81, 857-862.


I. Brandina, A. Smirnov, O. Kolesnikova, N. Entelis, I. Krasheninnikov, R. Martin & I. Tarassov (2007)  tRNA import into yeast mitochondria is regulated by the ubiquitine-proteasome system FEBS lett., 581, 4248-4254.


I. Tarassov, P. Kamenski, O. Kolesnikova, O. Karicheva, R. P. Martin, I. A. Krasheninnikov & N. Entelis (2007) Import of nuclear DNA-encoded RNAs into mitochondria and mitochondrial translation Cell Cycle, 20, 2473 - 2477.



Entelis, N. S., Brandina, I. L., Kamenski, P. A., Krasheninnikov, I. A., Martin, R. P. and Tarassov, I.  (2006) A glycolytic enzyme, enolase, is recruited as a co-factor of tRNA targeting towards mitochondria in Saccharomyces cerevisiae. Genes & Dev., 20, 1609-1620.


Brandina, I., Graham, J., Lemaitre-Guiller, C., Entelis, N. Krasheninnikov, I., Sweetlove, L., Tarassov, I., Martin, R. P. (2006) Enolase takes part in a macromolecular complex associated to
mitochondria in yeast
. BBA-Bioenergetics, 1757, 1217-1228.



Kolesnikova, O.A., Entelis, N.S., Jacquin-Becker, C., Goltzene, F., Chrzanowska-Lightowlers, Z., Lightowlers, R.N., Martin, R.P. and Tarassov, I. (2004). Nuclear DNA-encoded tRNAs targeted into mitochondria can rescue a mitochondrial DNA mutation associated with the MERRF syndrome in cultured human cells. Hum. Mol. Genet. 13, N°20, 2519-2534.


Kolesnikova, O.A., Entelis, N.S., Krasheninnikov, I.A., Martin, R.P., Tarassov, I.A. (2004) tRNA import inot mitochondria (a review). Progress in Biological Chemistry (Russian, translated in English) 44, 53-78.



Brandina, I. and Tarassov, I. (2003). Import d'ARN dans les mitochondries. Regard sur la Biochimie N°4, pp19-26.



Entelis, N., Kolesnikova, O. A., Kazakova, E. A., Brandina, I. L., Kamenski, P. A. Martin, R. P. and Tarassov, I. A. (2002) Import of nuclear encoded RNAs into yeast and human mitochondria: experimental approaches and possible biomedical applications. In: Genetic Engineering: Principles and Methods J. K. Setlow, ed. (New York, Oxford, Paris, Tokyo, Kluwer Academic/Plenum Press, U.S.A.), Vol. 24, pp.191-213.


Kolesnikova, O., Entelis, N., KAZAKOVA, H., BRANDINA, I., Martin, R. P. and Tarassov, I. (2002). Targeting of tRNA into mitochondria: the role of anticodon nucleotides. Mitochondrion 2/1-2, 93-105.



Entelis, NS, Kolesnikova, OA, Martin, RP, Tarassov IA (2001) Importation d'ARNt et maladies mitochondriales. Med Sci (Paris) 17, 91-93.


Entelis, NS, Kolesnikova, OA, Martin, RP, Tarassov IA (2001) RNA delivery into mitochondria. Advanced Drug Delivery Rev. 49, 199-215.


Entelis, N. S., Kolesnikova, O. A., Dogan, S., Martin, R. P., and Tarassov, I. A. (2001). 5S rRNA and tRNA import into human mitochondria: comparison of in vitro requirements, J. Biol. Chem. 276, 45642-45653.



Kolesnikova, OA, Entelis, NS, Mireau, H, Fox, TD, Martin, RP, Tarassov, IA (2000) Suppression of mutations in mitochondrial DNA by tRNAs imported from the cytoplasm. Science 289 (5486): p. 1931-1933 (highlighted in NATURE REVIEWS GENETICS)


Grava, S, Dumoulin, P., Madania, A., Tarassov, I.A., Winsor, B. (2000) Functional Analysis of six genes from chromosomes XIV and XV of Saccharomyces cerevisiae reveals YOR145c as an essential nuclear gene and YNL059c/ARP5 as a strain-            dependent essential nuclear gene , Yeast 16, 1025-1033.


Sidorik, L., T. Rybinska, N. Rodnin, V. Filonenko, N. Entelis, I. A. Tarassov, R. Martin, and G. K. Matsuka (2000). The immunological cross-reactivity between cytoplasmic and mitochondrial mammalian lysyl-tRNA synthetases. Biopolymers and Cell (Kiev). 16, 350-357.



Tarassov I.A., Entelis N.S., Martin R. (1999) tRNA import into yeast mitochondria: experimental approaches and possible applications. In : Mitochondrial diseases (Lestienne, ed.) Springer-Verlag Berlin Heidelberg, 303-316.


Kazakova H.A., Entelis N.S., Martin R.P., Tarassov I.A. (1999) The aminoacceptor stem of the yeast tRNALys contains determinants of mitochondrial import selectivity. FEBS lett. 442, 193-197.


Entelis N.S., Kieffer S., Kolesnikova O.A., R.  Martin, Tarassov I.A. (1998) tRNALys structural requirements for its import into yeast mitochondria. Proc. Natl. Acad. Sci. USA 95, 2838-2843.



Bordonné R., Camasses A., Madania A., Poch O., Tarassov I.A., Winsor B., Martin R. (1997). Analysis of a 35.6 kb region on the right arm of Saccharomycescerevisiae chromosome XV. Yeast ,   13, 73-83.


Dujon, B., Albermann, K., Aldea, M., Alexandraki, D. , Ansorge, W., Arino, J., Benes, V., Bohn, C., Bolotin-Fukuhara, M., Bordonné, R., Boyer, J., Camasses, A., Casamayor, A., Casas, C., Chéret, G., Cziepluch, C., Daignan-Fornier, B., Dang, D.V., De Haan, M., Delius, H., Durand, P., Fairhead, C., Feldmann, H., Gaillon, L., Galisson, F., Gamo, F.-J., Gancedo, C., Goffeau, A., Goulding, S.E., Grivell, L.A., Habbig, B., Hand, N.J., Hani, J., Hattenhorst, U., Hebling, U., Hernando, Y., Herrero, E., Heumann, K., Hiesel, R.u , Hilger, F.n , Hofmann, B.m , Hollenberg, C.P.s , Hughes, B.v , Jauniaux, J.-C.k , Kalogeropoulos, A., Katsoulou, C., Kordes, E., Lafuente, M.J., Landt, O., Louis, E.J., Maarse, A.C., Madania, A., Mannhaupt, G., Marck, C., Martin, R.P., Mewes, H.W., Michaux, G., Paces, V., Parle-McDermott, A.G., Pearson, B.M.t , Perrin, A.a , Pettersson, B.aa , Poch, O.i , Pohl, T.M.v , Poirey, R.k , Portetelle, D., Pujol, A., Purnelle, B., Ramezani Rad, M., Rechmann, S., Schwager, C., Schweizer, M., Sor, F., Sterky, F., Tarassov, I.A., Teodoru, C., Tettelin, H., Thierry, A., Tobiasch, E., Tzermia, M., Uhlen, M., Unseld, M., Valens, M., Vandenbol, M., Vetter, I., Vlcek, C., Voet, M., Volckaert, G., Voss, H., Wambutt, R., Wedler, H., Wiemann, S., Winsor, B., Wolfe, K.H., Zollner, A., Zumstein, E., Kleine, K. (1997). The nucleotide sequence of Saccharomyces cerevisiae chromosome XV. Nature 387, 98-102.


Entelis N.S., Krasheninnikov I.A., Martin R., Tarassov I.A. (1996). Mitochondrial import of tRNALysCUU in yeast: possible roles of modified nucleotides and aminoacylation. FEBS lett., 384, 38-42.


Bordonné R., Tarassov I. (1996). The yeast SME1 gene encodes the functional homologue of the human Sm E core protein. Gene, 176, 11-117.


Madania, A., Poch O., Tarassov I.A., Winsor B., Martin R. (1996). Analysis of a 22956 bp region on the right arm of Saccharomyces cerevisiae chromosome XV. Yeast ,   12, 1563-1573.


Kazakova E.A., Tarassov I.A. Entelis N.S.  (1996). Mitochondrial import of RNA. (A review). Molecular Biology Moscow (english translation from Molekularnaya Biologiya),  30, 438-443.


Tarassov I.A., Martin R.  (1996). Mechanisms of tRNA import in yeast: An overview. Biochimie, 78, 502-510.



Tarassov I.A., Entelis N.S., Martin R.P "Mitochondrial import of tRNA(Lys)cuu in S.cerevisiae requires an intact protein translocation machinery" (1995) J. Mol. Biol.  245,  315-323.


Tarassov I.A., Entelis N.S., Martin R.P "Mitochondrial import of a cytoplasmic lysine-tRNA in yeast is mediated by cooperation of cytoplasmic and mitochondrial lysyl-tRNA synthetases" (1995) The EMBO J.,  14,  3461-3471.