Labex MitoCross

MitoCross Projects for IMCBio Ph Call 2020

Projects for IMCBio fellowships with LabEx MitoCross participation:

1. MitoCross / NetRNA (Team P. Giegé (coDir. PhD, P. Giegé) / Team M. Frugier (coDir. PhD, C. Sauter)

               "Exploring the functional and structural diversity of NYN domain ribonucleases"

2. MitoCross / INRT (Team J. Schacherer (coDir. PhD, J. Schacherer) / Team G. Charvin (coDir. PhD, G. Charvin)

               "Role of rDNA genomic instability on replicative senescence in a natural population"

3. MitoCross/INRT (Team N. Entelis (coDir. PhD, I. Tarassov) / Team N. Charlet-Berguerand (coDir. PhD, N. Charlet-Berguerand)

               "Study of mitochondrial dysfunction in amyotrophic lateral sclerosis"

 

Projects for the MitoCross fellowship :

1. Team J. Gualberto (Dir. PhD, J. Gualberto)

               "MitoTALENs for the manipulation of the maintenance, segregation and editing of the mitochondrial genome"

2. Team H. Becker (Dir. PhD, H. Becker)

               "Role of mRNA binding by organellar echoforms of multi-localized aminoacyl-tRNA synthetases"

3. Team N. Entelis (Dir. PhD, B. Masquida, co-supervisor, A. Smirnov)

               "Study of mitochondrial ribosome assembly factors involved in neurodegenerative diseases"

The MitoCross LabEx consortium is composed of six laboratories based in Strasbimage d'une mitochondrieourg and working on various aspects of mitochondrial research, encompassing different models (yeast, plants, human) and different approaches (structural, biophysical, biochemical, functional and biomedical) and the associate partner, PolyPlus Transfection.

Mitochondria are essential intracellular organelles of eukaryotic cells responsible for a large number of processes: respiration, ATP-generation, synthesis of some amino acids, oxidation of fatty acids, regulation of reactive oxygen species, apoptosis, etc.

Mitochondria are implicated in the aging process, in many severe and mostly incurable neuromuscular and neurodegenerative syndromes, as well as in diseases such as Alzheimer's disease or some cases of cancer and diabetes. The peculiarity of these organelles protected by a double membrane is the presence of their own mitochondrial genome in their inner compartment, mtDNA. mtDNA differs in organization and size among species and codes for only few organellar macromolecules. Since most of the macromolecules are nuclear-encoded, mitochondrial biogenesis and activities, in health as well as in disease depend on a continuous cross-talk with the nucleo-cytosolic compartment of the cell.

 

In depth understanding ofmitochondria nucleus cross-talks these interaction and coordination mechanisms and characterization of the involved mitochondrial molecular machines are therefore of primary importance from both fundamental and medico-social points of view. The overall objective of the MitoCross network is to deepen the knowledge of the fine molecular mechanisms governing mitochondrial biogenesis, genetics and cross-talk with the nucleus, to characterize as many actors as possible in different organisms and to subsequently exploit this knowledge to understand the biochemical mechanisms underlying mitochondrial diseases, to envision agronomic applications and model innovative therapy approaches.




Executive board

Contact the executive board: contact-mitocross@unistra.fr

Ivan TARASSOV

Directeur de Recherche CNRS
i.tarassov@unistra.fr
Scientific manager of the MitoCross consortium
(responsible Team 1)